Genomics


Alex’s Lemonade Stand Foundation Pediatric Preclinical Genomic Characterization Project

The Pediatric Preclinical Testing Consortium (PPTC) gratefully acknowledges the support of Alex’s Lemonade Stand Foundation (ALSF) for the characterization of patient-derived xenograft (PDX) childhood cancer models with advanced genomic technology.

  • The ALSF contribution allowed the PPTC, in collaboration with the Baylor College of Medicine and Nationwide Children’s Hospital, to generate 152 new whole exome sequences, 105 new SNP array genotypes, and 237 RNA sequences.

  • The data will be available to all academically qualified petitioners through the database of Genotypes and Phenotypes (dbGaP) .

  • The data will be merged with existing Pediatric Preclinical Testing Program (PPTP) PDX sequencing data at the cBio portal , so that complete genomic data will be available on 237 PDX models across 23 unique childhood cancers.

  • A goal of the PPTC is to freely share data and models, and additional instructions will be provided when the data are fully available at the cBio Portal.