Dr. Li's laboratory is responsible for PPTC testing involving childhood cancer brain tumor models (e.g., medulloblastoma, ependymoma, high grade gliomas, etc.). Brain tumors are the leading cause of cancer-related death in children. To effectively prioritize drug candidates and improve chances of clinical success, Dr. Li's laboratory at the Baylor College of Medicine developed a large panel (>70) of patient-derived orthotopic xenograft models of malignant pediatric brain tumors. These models replicate the histopathological features and major genetic abnormalities of the original patient tumors and represent a broad spectrum of potential driver mutation/alternations in pediatric CNS tumors. Dr. Li's laboratory seeks to utilize this novel panel of patient-derived orthotopic xenograft models to examine the therapeutic efficacy of new agents and to understand mechanisms of action in order to establish preclinical rationale for expedited translation into clinical trials.
Baylor College of Medicine